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KMID : 0914820010010020092
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Journal of the Korean Gastric Cancer Association
2001 Volume.1 No. 2 p.92 ~ p.99
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Study of the Expression of E-cadherin, β-catenin, and c-Met in Gastric Adenocarcinomas
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Cho Seong-Jin
Kim Min-Kyung
Shin Bong-Kyung
Min Youn-Ki
Cho Min-Young
Seo Seong-Ok
Won Nam-Hee
Chae Yang-Seok
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Abstract
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Purpose: E-cadherin is an adhesion molecule essential for tight connection between cells, forming the cadherin/catenin complex. Truncated β-catenin disrupts the interaction between E-cadherin and α-catenin, leading to the loss of intercellular adhesion. Met protein, the hepatocyte growth factor receptor, plays important roles in signal transduction. We investigated the relationships between the expressions of E-cadherin, β-catenin, and c-met protein and the clinicopathological and prognostic parameters in gastric adenocarcinomas.
Materials and Methods: The patterns of E-cadherin, β-catenin, and c-met protein expression were studied using immunohistochemistry in formalin-fixed, paraffin-embedded archival tissues from 76 surgically resected gastric adenocarcinomas.
Results: Increased expressions of E-cadherin, β-catenin, and c-met were more significantly correlated in early gastric caners (EGC) than in advanced gastric cancers (AGC) (P=0.002, P=0.003 and P=0.026). The positive immunoreactivities of all three markers were markedly lower in signet ring-cell type and poorly differentiated type lesions than in intestinal-type lesions. Decreased expression of the β-catenin protein correlated well with increased tumor
invasion depth (P=0.039), and increased lymph node metastasis correlated well with reduced expression of c-met (P=0.046).
Conclusion: In gastric cancers, reduced expressions of the E-cadherin, β-catenin, and c-met proteins may play some role in poorer tumor differentiation, deeper tumor invasion, and increased lymph node metastasis. Also, the c-met gene is thought to play a specific role in the mechanism of the yet unknown catenin action.
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KEYWORD
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c-Met, E-cadherin, β-catenin, Gastric adenocarcinoma, Immunohistochemistry
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